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KMID : 0903520050480010065
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Journal of the Korean Society of Agricultural Chemistry and Biotechnology
2005 Volume.48 No. 1 p.65 ~ p.69
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Biological activity of St. John’s wort (Hypericum perforatum L.)
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Cho Young-Je
Chun Sung-Sook
Yoon So-Jung
Kim Jeung-Hoan
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Abstract
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The physiological activity of St. John’s wort extracts were examined. Total phenol contents in the ethanol extracts (246.0±10.5mg/ml) with St. John’s wort leaf was higher than that in water extract (237.4±13.2mg/ ml). The electron donating ability in the water extracts and in the ethanol extracts were 95.0% and 95.2% respectively. Antioxidant protection factor of the ethanol extract was higher than that of the water extract. The water extract from St. John’s wort leaves did not show an antimicrobial activity against Helicobacter pylori, but the ethanol extract revealed high antimicrobial activities such as 11mm of clear zone in 100mg/ml of phenol content and 13mm of clear zone in 150mg/ml of phenol content. The hot water extract showed an angiotensin converting enzyme inhibitory activity of 19.2%. The xanthin oxidase inhibitory activity of hot water and ethanol extract were very high, amounting to 84.8% and 100% respectively. The results suggested a possibility for developing the phenol compounds in St. John’s wort as anti Helicobacter pylori, anti-oxidant and anti-gout agents.
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KEYWORD
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St. John’s wort, biological activity, Helicobacter pylori, angiotensin converting enzyme, xanthin oxidase
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